1 Result for "

Alpinia oxyphylla Miq.

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Alpinia oxyphylla Miq." in MCE Product Catalog:

Globulol
Globulol
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Art. -Nr.: HY-N8389
CAS. Nr.: 489-41-8
Category:  

Terpenoids Sesquiterpenes Myrtaceae Plants Eucalyptus globulus Labill.

Target:  

Bacterial Fungal PAK Akt STAT PD-1/PD-L1 Apoptosis CCR

Globulol is a terpenoid metabolite and Antimicrobial agent. Globulol can be isolated from Alpinia oxyphylla Miq. Globulol binds to PAK4, reduces the expression level of PAK4 in cancer cells, decreases the phosphorylation of AKT, and downregulates the expressions of STAT3, phosphorylated STAT3, and PD-L1. Globulol promotes the secretion of CCL4 by cancer cells. Globulol reduces the viability and proliferation ability of cancer cells, induces G0/G1 cell cycle arrest and Apoptosis in cancer cells, and inhibits cancer cell migration and the integrity of 3D tumor spheres. Globulol enhances the relevant effects of anti-PD-1 agents in the cancer cell microenvironment. Globulol exhibits anticancer activity against liver cancer. Globulol inhibits the mycelial growth of phytopathogenic fungi and the growth of phytopathogenic bacteria. Globulol can be used in studies related to hepatocellular carcinoma .
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